Dr. Wiley develops methods for using data from electronic health records for precision medicine discovery and implementation. She is a principal investigator in the Colorado Center for Personalized Medicine and an assistant professor in the Division of Biomedical Informatics and Personalized Medicine at the University of Colorado Anschutz Medical Campus. She has a secondary appointment in the Department of Biostatistics & Informatics in the Colorado School of Public Health.

She completed a PhD in human genetics and Masters in biomedical informatics at Vanderbilt University. Her published work involves developing computational phenotyping algorithms for use in EHR-linked biobanks and investigating new algorithms for precision dosing of warfarin in African Americans. She also served as the lead informatician on an NIH Cancer Moonshot-funded project to create a comprehensive tobacco cessation service at the University of Colorado Cancer Center.  Her current work focuses on clinical evidence generation from electronic health records.

Dr. Wiley is active in the informatics community, serving on the editorial board of the Journal of Biomedical Informatics, as Vice-Chair of the 2021 American Medical Informatics Association Informatics Summit, and the 2019 AMIA Annual Symposium. Further she has co-developed the Coursera Clinical Data Science Specialization - a series of six MOOCs designed to teach clinical research informatics skills.