Learn more about the current research projects of the LEAD Center.
Principal Investigator: Dana Dabelea, MD, PhD
Researchers Involved: Dana Dabelea, Megan Kelsey, Deb Glueck
About the Study: Healthy Start Teens is the current follow-up phase of the ongoing Healthy Start Study. Through ongoing data collection from pregnant mothers and their babies, this phase follows 500 participants aged 8-15 to understand how puberty affects growth, weight, fat distribution, and diabetes risk. Type 2 diabetes (T2D) in youth has been increasing, but our understanding of how risk might relate to changes during puberty is limited. The goal is to uncover how early life exposures and genetic factors contribute to diabetes, obesity, and related conditions. This research aims to help predict and prevent youth-onset T2D, ultimately improving long-term health outcomes.
To learn more, visit healthystartstudy.org.
Principal Investigator: Dana Dabelea, MD, PhD
Researchers Involved: Dana Dabelea, Traci Bekelman, Wei Perng
About the Study: Environmental Influences on Childhood Health Outcomes (ECHO) is a nationwide study, funded by the National Institutes of Health (NIH). In 2016, the NIH awarded the Healthy Start Study with the ECHO grant, enabling the LEAD Center to continue its longitudinal research. The primary goal of Healthy Start ECHO is to understand how environmental factors during and after pregnancy influence the health of children and their mothers later in life. Participants include children (aged 8-15) and their moms that were enrolled into the Healthy Start Study cohort, making this a vital follow-up of longitudinal research.
For more information about ECHO go to https://echochildren.org/.
Principal Investigator: Dana Dabelea, MD, PhD
Principal Investigator: Dana Dabelea, MD, PhD
Researchers Involved: Dana Dabelea, Anne Starling, Brianna Moore
About the Study: Similar to the Healthy Start study, this study is apart of the Environmental Influences on Child Health Outcomes (ECHO) Study. Mile-High ECHO is a new cohort recruiting pregnant individuals and their partners, to study how exposures before and after birth affect child health outcomes. This research can be used to promote policy and practice that is aimed at reducing adverse environmental exposures. Our site works with Denver Health and University of Colorado Hospital to enroll a diverse group of participants. As part of the nationwide ECHO consortium, we will explore how early-life exposures impact the risk of obesity and neurodevelopment. Our goal is to identify ways to improve child health from preconception through early life.
Learn more at https://echochildren.org/ and https://www.milehighecho.org/
Principal Investigator: Dana Dabelea, MD, PhD
Researchers Involved: Dana Dabelea, Katherine Sauder, Allison Shapiro, Christy Hockett, Anna Bellatorre, Wei Perng
About the Study:
EPOCH is a longitudinal study of adolescents and their long-term health outcomes related to whether they were exposed to mother’s diabetes during pregnancy. While it is known that a mother with diabetes during pregnancy increases the risk of childhood obesity and diabetes, many other things are not known, including whether infant or childhood feeding changes these outcomes.
Principal Investigator: Dana Dabelea, MD, PhD, Principal Investigator
Researchers Involved: Dana Dabelea, Anna Bellatorre, Tessa Crume, Stephen Daniels, Richard Hamman, Michael Kahn, Joan O’Connell, Katherine Sauder, Lisa Testaverde
About the Study: SEARCH is a national multi-center population-based study aimed at understanding the burden of diabetes and its complications among youth and young adults. In five US centers (including the entire State of Colorado and American Indians in Arizona and New Mexico), new cases of all types of diabetes are identified and registered. Volunteers from this registry have joined a cohort study with long term follow-up to see what predicts the complications of diabetes (eye, nerve, kidney and heart disease) and how patterns of care and behavioral issues affect such persons. Projections of the future burden of diabetes have also been made.
Principal Investigator: Dana Dabelea, MD, PhD
Researchers Involved: Dana Dabelea, Janet Snell-Bergeon, Rebecca Conway
About the Study: SEARCH Cardiovascular disease (CVD) is a multi-center study that consists of both a cohort and registry. We aim to follow up with participants to understand how social determinants of health (SDOH) such as income, education, and access to healthcare, impact type 1 diabetes (T1D) care and outcomes. This study focuses on the disparities in CVD risk among diverse groups who face higher risks. CVD is the leading cause of death for people with T1D, and issues like heart dysfunction are common even in childhood. This study could help identify ways to prevent CVD and improve the heart health of those with T1D.
Principal Investigator: Dana Dabelea, MD, PhD
Researchers involved: Dana Dabelea, Leigh Perreault
About the Study: The DPPOS is the long-term follow-up of the landmark Diabetes Prevention Program (DPP) trial that showed that lifestyle changes or the drug metformin effectively delay diabetes in overweight or obese American adults. Follow-up now exceeds fifteen years and the participants are being studied for further diabetes, heart disease, as well as aging related changes, and cancer. Results from the 10 year follow-up showed that lifestyle and metformin continued to delay or prevent diabetes.
Principal Investigators: Katherine Sauder, PhD, Dana Dabelea, MD, PhD
Researchers involved: Katherine Sauder, Dana Dabelea, Jeffrey Powell, William Knowler (NIDDK)
About the Study: Tribal Turning Point (TTP) is a collaborative study that aims to prevent obesity and type 2 diabetes in American Indian youth through a culturally appropriate behavioral intervention. The SEARCH for Diabetes in Youth Study revealed that this population was at highest risk for developing type 2 diabetes emphasizing the urgent need for early intervention. The study developed interventions in two differing tribal locations, the Navajo Nation and Eastern Band Cherokee. Participants joined activities centered on age-appropriate weight gain, physical activity, and food preparation based on local diets. Results from the study showed improved obesity measures, but future work will evaluate the program's effectiveness and long-term impact.Principal Investigators: Tessa Crume, MSPH, PhD
Researchers involved: Tessa Crume, Dana Dabelea
About the Study: Assessing the Burden of Diabetes by Type in Children, Adolescents, and Young Adults (DiCAYA A) is a multicenter study funded in 2020. We investigate the burden of diabetes in youth (ages 0-17) and young adults (ages 18-45) using electronic health records to monitor diabetes and determine its type and onset. This study builds off the findings from our SEARCH study and shows that diabetes among youth is rising. The DiCAYA A team includes experts in diabetes epidemiology and health informatics, aiming to provide accurate estimates of diabetes incidence and prevalence. This research can help identify health disparities and improve strategies to prevent diabetes nationwide.Principal Investigators: Tessa Crume, MSPH, PhD
Researchers involved: Tessa Crume, Dana Dabelea
About the Study: People with diabetes are at high risk for serious health complications that can diminish their quality of life. DiCAYA B focuses on monitoring type 1 and type 2 diabetes in young adults (ages 18-45) to understand its prevalence and incidence. Using electronic health records and other data sources in Colorado, the DiCAYA team aims to identify health disparities and improve prevention strategies. The study can provide crucial insights into diabetes trends by age, sex, race, and ethnicity, helping to inform healthcare systems and public health efforts.