Learn more about the current research projects of the LEAD Center.
Prinicipal Investigator: Dana Dabelea, MD, PhD
Researchers Involved: Dana Dabelea, Deborah Glueck, Susan Johnson, Brianna Moore, Brandy Ringham, Katherine Sauder, Allison Shapiro, Mercedes Martinez
About the Study: Through on-going data collection from pregnant mothers and their babies, who are now 4-6 year old children, we are studying the metabolic and behavioral factors during pregnancy and early life that contribute to the development of obesity and related health problems.
To learn more, visit healthystartstudy.org.
Principal Investigator: Dana Dabelea, MD, PhD
Researchers Involved: Dana Dabelea, Katherine Sauder, Allison Shapiro, Christy Hockett, Anna Bellatorre, Wei Perng
About the Study:
EPOCH is a longitudinal study of adolescents and their long-term health outcomes related to whether they were exposed to mother’s diabetes during pregnancy. While it is known that a mother with diabetes during pregnancy increases the risk of childhood obesity and diabetes, many other things are not known, including whether infant or childhood feeding changes these outcomes.
Principal Investigator: Dana Dabelea, MD, PhD, Principal Investigator
Researchers Involved: Dana Dabelea, Anna Bellatorre, Tessa Crume, Stephen Daniels, Richard Hamman, Michael Kahn, Joan O’Connell, Katherine Sauder, Lisa Testaverde
About the Study: SEARCH is a national multi-center population-based study aimed at understanding the burden of diabetes and its complications among youth and young adults. In five US centers (including the entire State of Colorado and American Indians in Arizona and New Mexico), new cases of all types of diabetes are identified and registered. Volunteers from this registry have joined a cohort study with long term follow-up to see what predicts the complications of diabetes (eye, nerve, kidney and heart disease) and how patterns of care and behavioral issues affect such persons. Projections of the future burden of diabetes have also been made.
Principal Investigator: Dana Dabelea, MD, PhD
Researchers involved: Dana Dabelea, Leigh Perreault
About the Study: The DPPOS is the long-term follow-up of the landmark Diabetes Prevention Program (DPP) trial that showed that lifestyle changes or the drug metformin effectively delay diabetes in overweight or obese American adults. Follow-up now exceeds fifteen years and the participants are being studied for further diabetes, heart disease, as well as aging related changes, and cancer. Results from the 10 year follow-up showed that lifestyle and metformin continued to delay or prevent diabetes.
Principal Investigators: Katherine Sauder, PhD, Dana Dabelea, MD, PhD
Researchers involved: Katherine Sauder, Dana Dabelea, Jeffrey Powell, William Knowler (NIDDK)
Abstract: TTP is exploring a culturally appropriate behavioral intervention to prevent obesity, increase physical activity and eventually prevent type 2 diabetes in American Indian youth, the population with the highest rates in the US. A successful pilot study with Eastern Band Cherokee and Navajo youth is being followed up with a larger trial including both Navajo on reservation and American Indians in the Phoenix urban area.
Background: American Indian (AI) youth are at high risk for type 2 diabetes.
Objectives: To partner with Eastern Band of Cherokee Indians and Navajo Nation to develop a culturally sensitive behavioural intervention for youth (Tribal Turning Point; TTP) and assess feasibility in an 8-month randomized pilot study. Methods: We enrolled 62 overweight/obese AI children (7–10 years) who participated with ≥1 parent/primary caregiver. Intervention participants (n = 29) attended 12 group classes and five individual sessions. Control participants (n = 33) attended three health and safety group sessions. We analyzed group differences for changes in anthropometrics (BMI, BMI z-score, waist circumference), cardiometabolic (insulin, glucose, blood pressure) and behavioural (physical activity and dietary self-efficacy) outcomes.
Results: Study retention was 97%, and intervention group attendance averaged 84%. We observed significant treatment effects (p = 0.02) for BMI and BMI z- score: BMI increased in control (+1.0 kg m2, p < 0.001) but not intervention participants (+0.3 kg m2, p = 0.13); BMI z-score decreased in intervention (-0.17, p = 0.004) but not control participants (0.01, p = 0.82). There were no treatment effects for cardiometabolic or behavioural outcomes.
Conclusions: We demonstrated that a behavioural intervention is feasible to deliver and improved obesity measures in AI youth. Future work should evaluate TTP for effectiveness, sustainability and long-term impact in expanded tribal settings.
Publication: Sauder KA, Dabelea D, Bailey-Callahan R, Kanott Lambert S, Powell J, James R, Percy C, Jenks BF, Testaverde L, Thomas JM, Barber R, Smiley J, Hockett CW, Zhong VW, Letourneau L, Moore K, Delamater AM, Mayer-Davis E: Targeting risk factors for type 2 diabetes in American Indian youth: the Tribal Turning Point pilot study. Pediatr Obes 2017;DOI: 10.1111/ijpo.12223